|Assistant Professor of Biology|
|Office:||Keck Science Center 212|
|Office Hours:||Tues 10:00 - 12:00 pm, Thurs 10:00 - 11:00 am|
|Post-doc Plant Gene Expression Center, UC Berkeley
Ph.D. Washington State University, Molecular Plant Sciences
B.S. SUNY at Plattsburgh, Biochemistry
|BIOL040L Introduction to Biological Chemistry
BIOL043L Introductory Biology
BIOL156L Genomics and Bioinformatics
|The ubiquitin / 26S proteasome system (UPS) is a major pathway accomplishing cellular change in eukaryotes. The UPS is required for important biological processes ranging from hormone signaling in plants to cell cycle progression in humans, where its mis-regulation has been associated with some types of cancer. The UPS alters the cellular state by selective removal of target proteins, which can be key repressors or activators of gene expression. Within the UPS, a ubiquitin ligase marks targets for removal by attaching ubiquitin, a small 76-residue protein. The SCF complex is one type of ubiquitin ligase composed of three core subunits plus an F-box protein. F-box proteins are interchangeable, and they specifically interact with and recruit diverse targets to the core complex for ubiquitylation and consequent removal by the 26S proteasome. Remarkably, plant genomes are highly enriched in F-box genes relative to other eukaryotes, with approximately 700 encoded in the model plant Arabidopsis thaliana. This enrichment implies both a broad target range and a heavy reliance on the UPS in plant-specific processes and, furthermore, establishes plants as a particularly good system in which to study the UPS. The overwhelming majority of these predicted F-box proteins are of unknown biological function. Because plants require distinctive strategies to survive environmental stresses, our global hypothesis is that many of these F-box proteins help alter the physiological state of the plant cell and assist in stress adaptation. The immediate goal of my lab is to identify specific F-box genes acting under defined stresses that could help plants survive adverse environmental conditions.
We use both functional genomic and molecular genetic approaches to identify and then characterize F-box genes that potentially act in stress responses. Our findings contribute to the understanding of how plants deal with environmental stress, as well as to how the UPS works in eukaryotic cells.
|Selected Publications List: Click to open new window.|