Keck Science :: Faculty and Staff : Faculty Profile

Zhaohua Irene Tang

Associate Professor of Biology

Email:

ztang@kecksci.claremont.edu

Office:

Keck Science Center 201

Phone:

909-607-9067

Office Hours:

Web Site:

Educational Background:

Peking University Medical School, Beijing, P. R. of China
B.S. State University of New York at Stony Brook
Ph.D. University of California, Los Angeles
Postdoctoral Fellow, California Institute of Technology, Pasadena, CA

Courses Taught:

Regulation of the Cell-division Cycle (lecture)
Physical Chemistry for Molecular Biology Program (lecture)

Introductory Biology, lecture and lab
Cell Biology, lecture and lab
Cell Cycle, Diseases, and Aging (lecture)
Biology 177 Biochemistry (Lecture)

Research Interests:

To investigate the functions of several protein kinases in the regulation of cell cycle progression and cell death, in the response to environmental factors, as well as in the cellular sensitivity to anticancer drugs, using a single-cell eukaryotic organism, fission yeast Schizosaccharomyces pombe as an in vivo model.

Thesis Topics:

1. Cell signaling for the interplay between cell-division cycle and gene expression events such as pre-mRNA processing in eukaryotes involving several protein kinases including Dsk1p and Kic1p.
2. Genes required for the cellular sensitivity and resistance to platinum-based anticancer drugs.
3. Response networks for environmental phenol stress factors

Selected Publications List: Click to open new window.

1. Zhaohua Tang, Maria Luca, Laura Taggart-Murphy, Jessica Portillio, Cathey Chang, Ayse Guven, Ren-Jang Lin, Johanne Murray, and Antony Carr . (2012). Interacting Factors and Cellular Localization of SR Protein-specific Kinase Dsk1.. Experimental Cell Research 318 (16): 2071-2084. Abstract Article

2. Zhaohua Tang, Maria Luca, Jessica Portillio, Benson Ngo, Cathey Chang, Teresa Wen, Johanne Murray, and Antony Carr . (2011). LAMMER Kinase Kic1 Is Involved in Pre-mRNA Processing. . Experimental Cell Research 317: 2308-2320. Abstract Article

3. Zhaohua Tang . (2010). The Domino and Clock Models of Cell Cycle Regulation. Nature Education 3(9): 56. Article

4. Nicole M. Duggan* and Zhaohua Tang . (2010). The Formation of Heterochromatin and RNA interference. Nature Education 3(9): 5. Article

5. Tang, Z., Alaei, Tsurumi, A., C., Wilson, C., S., Chiu, C., Oya, J., and Ngo, B. . (2007). Dsk1 Kinase Phosphorylates SR Proteins and Regulates Their Cellular Localization in Fission Yeast. . Biochemical Journal 405 (1): 21-30. Abstract Article

6. Huang, C-J, Tang, Z, Lin, R.-J, and Tucker, P.W. . (2007). Phosphorylation by SR kinases regulates the binding of PTB-associated splicing factor (PSF) to the pre-mRNA polypyrimidine tract. . FEBS lett 581(2): 223-232. Abstract

7. Tang, Z., Mandel, L., Yean, S.-L., Lin*, C.X., Chen*, T., Yanagida, M., and Lin, R.-J. . (2003). The Kic1 Kinase of Schizosaccharomyces pombe Is a CLK/STY Orthologue That Regulates Cell-Cell Separation. Experimental Cell Research 283: 101-115. Abstract Article

8. Portal, D., Lobe, G.S., Kadener, S., Prasad, J., Espinosa, J.M., Pereira, C.A., Tang, Z., Lin, R.-J., Manley, J.L., Kornblihtt, A.R., Flawia M.M., and Torres H.N. . (2003). Trypanosoma cruzi TcSRPK, The First Protozoan Member of The SRPK Family, Is Biochemically and Functionally Conserved with Metazoan SR Protein-specific Kinases. Molecular and Biochemical Parasitology 127: 9-21. Abstract Article

9. Portal, D., Espinosa J.M., Lobo G.S., Kadener S., Pereira C.A., De La Mata M., Tang Z., Lin R.-J., Kornblihtt A.R., Baralle F.E., Flawia M.M., and Torres H.N. . (2003). An Early Ancestor in The Evolution of Splicing: A Trypanosoma Cruzi Serine-arginine-rich Protein (TcSR) Is Functional in Cis-splicing. Molecular and Biochemical Parasitology 127: 37-46. Abstract Article

10. Tang, Z., Käufer, N. F., and Lin, R.-J. . (2002). Interactions Between Two Fission Yeast SR-Related Proteins and Their Modulation by Phosphorylation. Biochemical Journal 368: 527-534. Abstract

11. Tang, Z., Kuo*, T., Shen*, J., and Lin, R.-J. . (2000). Biochemical and Genetic Conservation of Fission Yeast Dsk1 and Human SRPK1.. Mol. Cell. Biol 20(3): 816-824. Abstract Article

12. Tang, Z., Yanagida, M., and Lin, R.-J. . (1998). Fission Yeast Mitotic Regulator Dsk1 Is an SR Protein-Specific Kinase.. J. Biol. Chem 273: 5963-5969. Abstract Article

13. Coleman, T.R., Tang, Z., and Dunphy, W.G. . (1993). Negative Regulation of the Weel Protein Kinase by Direct Action of the Nim1/Cdr1 Mitotic Inducer. Cell 72: 919-929.

14. Tang, Z., Coleman, T.R., and Dunphy, W.G. . (1993). Two Distinct Mechanisms for Negative Regulation of the Wee1 Protein Kinase.. EMBO 12(9): 3427-3436. Abstract